Iyo Nhoroondo Uye Zviripo ZvemaSARM-Evhangeri YeSARMs
Kuita kwekusimudzira zvinodhaka kwagara kuchishamisa uye kumutsa kutaridzika kwevanhu. Kubva kuVaRoma vekare kusvika kumaGiriki, kushandiswa kwezvinhu zvinowedzera kushanda senge machende emhuka nemishonga zvainge zvakapararira uye zvichizivikanwa pasi rose. Nekufamba kwenguva, izvi zvinhu zvakatsiviwa nevanabolic macomputer uye prohormones ayo akabatsira vatambi uye vavaki vemuviri kuputsa mabani uye kuwana mukana wakasarudzika pamusoro pevatambi venyama. Nekudaro, paive nenjodzi hombe nekushandiswa kwemakemikari aya uye njodzi dzakanyanya kukura kupfuura zvakanakira
Ichi chaingova chimwe chezvikonzero nei makemikari evanabolic akarambidzwa nemitambo yemitambo uye hurumende dzenyika nekuda kwemhedzisiro yakaipa inosangana navo. Idzi ndidzo nguva apo nyika yekuvaka muviri neyemitambo yaitsvaga imwe nzira yakachengeteka uye ikauya Sarudzo uyerogen receptor modulators (SARM).
Kusarudza uyerogen receptor modulators akauya mukurumbira mushure mezvakakanganiswa zvemakomputa senge steroids akajekeswa nezvidzidzo zvakasiyana zvekurapa nekutsvaga. Anabolic steroids iyo yakambotemerwa pachirongwa chaifanira kutsiviwa nedzimwe nzira dzakachengeteka uye dzine simba. Vatengi vaitsvaga akachengeteka uye epamberi ekuvaka mhasuru vamiririri ayo anogona nyore kutengwa uye zvine hungwaru painternet pane kubata nevanhu vane mumvuri mumakamuri ekuvharira.
Kuwanikwa uye kufarirwa kwemaSARM munharaunda yesainzi kwaive chokwadi chiitiko chakakosha kune ese anopokana nekukwegura nemasangano ekurapa. Kunetseka kwakanyanya ne androgen kurapa kwaive kushomeka kwekuwanikwa kwemakomputa akachengeteka uye akasimba ekupa kunze kwemhedzisiro mhedzisiro inokonzerwa neyakajairika manejimendi eema androgens.
Chinangwa chikuru chevazhinji vevatsvagiri veSARM kwaive kuwana ruzivo uye njere nezve maagonist eiyo androgen receptor pasina mukana wekuti ubatanidze uye unoshanda searomatase uye 5a-reductase substrates. Nekufamba kwenguva, makambani emishonga uye vaongorori vakakwanisa kuvandudza zvakanyanya mushure mekunge zvave pachena kuti makemikari ekugadzirisa bicalutamide, iyo anti-androgen, yakagadzira uyerogen neagonistic chiitiko. Munguva pfupi, akasiyana makirasi e Selective androgen receptor modulators akaonekwa uye akagadzirwa.
Makambani makuru ekugadzira mishonga aive kumashure kweaya matsva ekurapa mamiriro akaomarara ehutano kwete eindasitiri yekuvaka muviri. Semuenzaniso, vaida kugadzira mishonga yekudzivirira kuparara kwemhasuru muvarwere vane gomarara neHIV / AIDS.
MaSARM Anoshanda Sei Chaizvo?
Tsinga dzemhasuru dzinoenderera pakuderera nekupera zera nekuda kwekuparara uye kurasikirwa kunotevera kwerudzi rwechipiri mhasuru tambo. Iyi mhasuru fiber mhando yakakosha pasimba, kutsungirira, uye kuwanda kwehutano hwekuita uye kuderera kwayo kunogona kutyisidzira iko kutsetseka uye kwakajairika mashandiro ezviitwa zvezuva nezuva.
Ongororo dzinoverengeka dzakaratidza kuti kudzidziswa uye kurovedzwa senge kuramba kudzidziswa kunogona kubatsira mukumutsa kuwedzera uye kuchengetedza mhando 2 mhasuru fiber. Iwo mazinga esimba uye akaonda tsandanyama mashoma anogona kukwidziridzwa mune vanhu vane uyerogen kushomeka nekuwedzera Selective uyerogen receptor modulators mumusanganiswa.
Sarudzo uyerogen receptor modulators inoshanda mumuviri kuburikidza:
- Kuramba kune aromatase iyo inoshandura kutendeuka kwe testosterone kuita estrogen.
- Kuratidzira kusangana kwakasarudzika nemhasuru uye pfupa tishu asi kwete chiropa, itsvo, prostate, uye moyo matishu.
- Kwete kupaza kuita marara mamorekuru ayo angadai akonzeresa kune steroid-senge mhedzisiro.
- Kwete kudzvinyirira iyo yakasikwa kugadzirwa kwemahormone senge testosterone.
Pamusoro pezvakanaka izvi, anosarudza uyerogen receptor modulators haikanganise kana kuisa kushushikana panhengo dzemuviri. Ivo havanyatso kuvharira zvakanyanya kana zvechigarire Hypothalamus-Pituitary-Testes-Axis (HPTA). Chinhu chakanakisa ndechekuti kushandiswa kweSARMs kusingaite kweanabolic androgenic steroids hakukonzere mhedzisiro senge kukura kwemazamu evarume, ganda rine mafuta, acne, kukuvara kweprostate, kudzikira kwetende muvarume, kudzika kwezwi uye zvisina kujairika kumwedzi kutenderera mumadzimai, uye kukura kwebvudzi kumeso, mudumbu, uye kumusoro kumashure.
Zvakare, kurapwa-kunotungamirwa kushandiswa kweyekutsvagisa-giredhi uye chaiwo maSARM ekurapa uye epamutemo zvinangwa zvakanyatso kuteedzana neyekurapa mirairo hazvikonzere mhedzisiro senge kuwedzera hukasha, kurasikirwa kwebvudzi, kukuvara kwekubereka, kana prostate matambudziko
Misiyano Mune Inosarudza Androgen Receptor Modulators
Imwe yemisiyano mikuru pakati pe Sarudzo uyerogen receptor modulatorsuye macomputer akafanana nevanabolic steroid ndiko kusiana kwechimiro pakati pavo. Izvo zvakakosha kuti uzive kuti chero komponi ine mukana wekusunga kune iyo androgen receptor yemuviri uye inogoneswa mune chaiwo maturu inogona kunzi seSarudzo Inosarudza uyerogen receptor modulator.
Chaizvoizvo, izvi zvinoreva kuti pane zvishoma kune kurongeka kwechimiro kuseri kwezita remazita zvichienzaniswa neiyo yevanabolic androgenic steroids (4-ring base).
Kusarudza Ndiko Kiyi
Inosarudza uyerogen receptor modulator yekufungidzirwa seinobatsira pakurapa inofanirwa kuratidza yakanaka tema kusarudza. Mune mamwe mazwi, inofanirwa kuratidza agonist chiitiko mupfupa uye mhasuru ichiratidzira kushoma kana kusawirirana nemaviri epabonde matishu akadai seprostate uye seminal vesicles.
Zvinogona kutaurwa kuti yakanaka Selective uyerogen receptor modulator ndiyo inosarudzika inosimudzira kukura kwemhasuru asi ichisiya iyo prostate, chiropa, bvudzi rebvudzi, uye mazamu ega. Uyezve, iyo SARM inofanirwa kuve iine zviitiko zvevanabolic zvakafanana kana zvimwe pamitsetse yeTesttosterone.
Chazvino Chimiro cheSARMs Pane Iyo WADA Yakarambidzwa Chinyorwa
Kubva 2008, Selective androgen receptor modulators zvakarambidzwa neWorld Anti-Doping Agency (WADA). Izvi ndezve chikonzero chiri nyore chekuti maSARM mishonga ine hunyanzvi ine akasiyana akasiyana mabhenefiti ayo anogona kupa hukuru "kusarongeka" kumucheto kune mutambi pamusoro pemakwikwi. Parizvino, Selective androgen receptor modulators inorambidzwa kune-ese-nguva muchikamu che "mamwe maanabolic agents" pasi peChikamu S1.2 che WADA Yakarambidzwa Chinyorwa. Izvi zvinoreva kuti iwe unofanirwa kudzivirira zvachose kushandisa maSARM kana kunyatso shandisa kana iwe uri mutambi akaedzwa saiye kuvapo kwe Selective androgen receptor modulatorsmumasampuli ako anogona kukuisira iwe mumatambudziko akadzika.
Parizvino Zuva Mukurumbira Mamiriro EmaSARM
Nhasi, Selective Androgen Receptor Modulators inorapwa sekirasi yakasarudzika yemamorekuru ayo anokwanisa kurapa zvinyoro kusvika kune zvakakomba mamiriro ehutano senge osteoporosis, kuparara kwemhasuru, uye kushomeka kwe androgen.
Vatambi uye varimi vemuviri vari kushandisa maSARM kurasikirwa nemafuta, kunatsiridza kuwanda kwemapfupa, uye kuwana tsandanyama dzakawandisa pavanenge vachigara kure nekutyisa mhedzisiro yemishonga yakadai seanabolic androgenic steroids. Kwete izvi chete, Selective Androgen Receptor Modulators inoshanda zvakanyanya kurapa kurasikirwa kwe libido, kushaya mbereko, uye nemanzwiro ekuora mwoyo, kuneta, kushomeka kuvimba, uye kushaya rukudzo apo uchivandudza hutano hwese uye pfungwa yekugara zvakanaka.
Pamusoro pezvakanaka izvi, maSARM anoyemurwa pasirese nekuda kwekukwira kwavo kuve bioavailability. Iyi mukana wakasarudzika unovaita ivo vanokodzera kukwikwidza kwekushandisa zvine mutsindo uye kunwa.
Parizvino, varimi vanovaka muviri vari kuwedzera uye vari kushandisa fomu rakapetwa rezvikonzero chaizvo uye zviri pachena. Iyi fomu yeSelection Androgen Receptor Modulators ine mikana isingaverengeke:
- Yakavharwa maSARMzviri nyore kutumira.
- Ivo vane hwakareba masherufu hupenyu pane emvura maSARM.
- Akavharwa maSARM anonyanya kufadza kune vashandisi vekupedzisira (sekugovana tsono kunodzivirirwa, mikana yezvirwere zvepabonde zvinotapudzwa, uye mukana wekurwadziwa kana kuzvimba panzvimbo dzejekiseni wabviswa).
- Zvimwe zveSARM zvinoshandiswa zvinorasikirwa nesimba uye zvinobudirira mune remvura fomu.
- Izvo zvinongedzo mune emvura maSARM akafanirwa kubatanidzwa nechikafu chakagayiwa uye kubuda kunze kwemuviri nekukurumidza. Kune rimwe divi, maSARM akavharirwa akagadzirwa nechinangwa chakatemerwa kubvumira muviri kuti unwe uye uchengete zviitiko zvakanaka zvezvinhu zvinobatsira zveSARM.
- Yakavharwa maSARMhauna mafirita asingakoshi senge mavara ekugadzira uye zvinowedzerwa.
Hazvishamise kuti nyika yekuvaka muviri iri kupenga pamusoro peizvi zvakachengeteka uye zvine simba zvekusimbisa muviri izvo zvakatombo shandura nyika yekusimudza uye kushanda kwakanyanya. Nekudaro, zvakakosha kwazvo kuti iwe ugare uchiona kuti Selective androgen receptor modulators inofanira kugara ichitengwa chete kubva kune zviri pamutemo SARM Chitoroiyo inobata mune yechokwadi uye yekutsvagisa-giredhi inosarudza uyerogen receptor modulators. Iyo yepamhepo maSARM Chitoro inofanirwa kupa yakachengeteka uye yakachengeteka nzira dzekubhadhara uye sarudzo yekuchenjera kurongedza uye kutumira zvigadzirwa mushure mekukudzidzisa zvizere nezve iyi mishonga kuitira kuti iwe ugare uchiita sarudzo ine ruzivo.
Zvakare, kushandiswa kwemishonga iyi ine simba zvikuru kunofanira kugara kuchiitwa zvizere maererano nemirayiridzo yezvokurapa uye zvemishonga nezvinangwa zviri pamutemo. Masosi eSARM haafanire kuwedzerwa uye mishonga iyi haifanire kushungurudzwa netariro yekukurumidza kutsvaga sezvo kushungurudzwa kwechero mushonga kunogona kutungamira kumhedzisiro uye kusarudza uyerogen receptor modulators hazvisi izvo. Sarudzo uyerogen receptor modulators mishonga ine simba inofanirwa kugara ichishandiswa zvine mutsindo.