SARMS YEMAHARA TESTOSTERONE
MaSARM Ekurapa Hypogonadism
Mumakore achangopfuura, huwandu hwevanhu vanokanganiswa neakasiyana siyana ezvirwere zvehutano nematambudziko. Chirwere chinononoka asi chichiwedzera kupararira chiMurume hypogonadism, inozivikanwawo sekushomeka kwe testosterone. Muchikamu cheruzivo ichi, tichave tichiverenga nezve iyi hutano mamiriro uye nekusarudza uye androgen receptor modulators inogona kushandiswa kurapa hypogonadism.
Hypogonadism-Ongororo
Hume hypogonadism inogona kuverengerwa sehutano mamiriro umo muviri wemunhu usingaburitse yakawanda ye testosterone. Rangarira, testosterone ndiyo hormone inotamba-yakakosha chikamu mukukura kwevanhurume uye kukura mukati mechikamu chekuyaruka. Iyi hutano mamiriro inogona zvakare kushandiswa kuratidza kukanganisika kugona kwemuviri kuburitsa urume.
Hypogonadism inogona kunge iri mamiriro munhu anozvarwa aine kana inogona kukura gare gare muhupenyu, kazhinji kubva kuhutachiona kana kukuvara. Vanhurume hypogonadism vanogona kurapwa nekusarudza uyerogen receptor modulators.
Hypogonadism Kurapa Sarudzo
Munguva yakapfuura, akawanda testosterone gadziriro aishandiswa pakurapa hypogonadism mune murume akwegura. Aya marapirwo ekurapa akasiyana mukuwanikwa kwavo kwematunhu, kuchinjika, mari, uye nyore. Pazvirapi zvese zviripo, kurapwa ne Selective androgen receptor modulators (SARMs) inoonekwa seyakanyanya kunaka. Izvi zvinonyanya kukosha nekuti maSARM anoratidza uye anopa vanobatsiro mukushayikwa kwe androgenic mhedzisiro pane bvudzi, ganda, uye prostate.
Izvo zvakakosha kuti uzive pano kuti kunonoka kutanga hypogonadism inosanganisira yakawanda rondedzero yezviratidzo nezviratidzo zvinosanganisira asi zvisingaite kune kuneta, kusagadzikana pabonde, yakaderera mutete wemuviri, uye kuderedzwa kwemaminetsi emaminetsi emaminetsi. Zvese izvi zviratidzo nezviratidzo zvinosanganisirwa neyakaderera testosterone mazinga uye kazhinji anotyaira murwere kunotsvaga rubatsiro rwekurapa.
Muna 1990s, Selective androgen receptor modulators (SARMs) dzakashumwa seasisteroidal androgen receptor agonists. Aya macompound aive neakasarudzika pharmacology uye anoshanda seakazara maagonist mune vanabolic matishu akadai sepfupa uye mhasuru asi akasarudzika agonist mune e androgenic matukisi senge ganda, bvudzi, uye prostate. Iyi yakasarudzika uye isingaenzanisirwe mukana weKusarudza uyerogen receptor modulators yakazivikanwa nekukurumidza nevatsvagiri uye vezvekurapa.
Semuyenzaniso, Ostarine (Enobosarm) yakaongororwa nekushanda kwayo uye hunhu hunhu pahunhu hwepanyama uye nekuumbwa kwemuviri muzvidzidzo zvakasiyana zvemakiriniki. Mukudzidza, 3mg yeOstarine kana placebo yakapihwa kumadzimai makumi mana nemasere ekumiraopaopausal kwemavhiki gumi nemaviri. Ostarine yakawedzera zvakanyanya kuwanda kwemuviri wemuviri pakuenzanisa ne placebo (48 kg; P <12). Kwete izvi chete, Ostarine (inozivikanwawo seMK-1.54) yakawedzera chidya chetsinga vhoriyamu ne0.001L kubva kune yekutanga uye zuva 2866 zvichienzaniswa nekudzikiswa kwe0.17L muboka re placebo. A 84 lbs kuwedzera kwakacherechedzwa musimba mhasuru musimba muboka reOstarine rekurapa zvichienzaniswa ne0.12 chete lb muvarwere vanogamuchira placebo.
Mune imwe yakasiana-yekupindura-yekudzidza, zvidzidzo zvakagashirwa placebo kana Ostarine pamiyero yezuva nezuva ye0.1, 0.3, 1.0, kana 3.0 mg kwemavhiki gumi nemaviri. Chidzidzo ichi chaisanganisira mazana makumi maviri evarume vane hutano vane makore ari pasi pemakumi matanhatu emakore uye vakadzi vanopera kuenda kumwedzi. Ostarine dhizaini-inotsamira yakawedzera iwo mwero wehuremu hwakazara hwemuviri uye nekudzora huwandu hwemafuta panguva imwe chete. Ostarine pachiyero che12 mg yakawedzera huremu hwemuviri hwakaonda ne120kg (P <60) iyo yaiperekedzwa nekuderedzwa kweanosvika 3.0kg (P = 1.3) mumafuta akazara anoenderana ne placebo. Iwo ekutsvagisa zvidzidzo zvakare akaratidzira kuwedzera-kunoenderana nedosi mukukwira kwesitepisi simba (P = 0.001). Ivo zvakare vakaratidza kuvandudza munguva inodiwa kukwira matanho gumi nemaviri.
Mune kumwe kudzidza, Ostarine uye placebo zvakapihwa kune 159 varwere vane akasiyana cancer. Dzidzo dzekutsvaga dzakasangana nekuwedzera kunoshamisa mushure memwedzi mina yekurapwa kweOstarine maererano nehuremu hwakazara hwemuviri pa1.0 mg (1.5kg; P = 0.0012) uye 3.0 mg (P = 0.046). Zvakare, pakanga paine avhareji yekuwedzera kwe18 muzana ye1mg (P = 0.001) uye 21.7 muzana ye3mg (P = 0.0065 pa3mg) yakacherechedzwa musitepisi kukwira simba nekuvandudza kunoshamisa munguva inodiwa kukwira matanho gumi nemaviri.
Ruzhinji rwezvigadzirwa zve testosterone zvinogamuchirwa pakurapa hypogonadism inoda hutungamiri hwevabereki. Iwo mazinga e testosterone anogona kudzoreredzwa kune akatsiga-nyika kuburikidza akasiyana nzira dzekutakura uye mafomati. Nekudaro, zvizhinji zvezvigadzirwa izvi kana zvichishandiswa kuburikidza nemajekiseni etsinga mumuviri zvinoguma nekuchinja kukuru mukupararira kwe testosterone. Zvakare, ivo vari kwenguva refu vachiita (2-14 mavhiki) ayo anotitadzisa nekukurumidza dhizaini kugadzirisa kana kumira kana zviitiko zvakashata.
Kune rimwe divi, maSARM akadai seOstarine anokwanisa anabolic mabhenefiti pane yakaderera milligram doses. Iyi yemuromo isingabvumirwe mishonga inoratidzwa zvakare nekubvisa kwenguva yakareba hafu-yehupenyu iyo inotungamira kushoma yepamusoro-kune-yekumusoro kuchinja. Izvi zvinoitisawo maSARM anokwanisika kamwe chete pazuva kuyerwa.
Tenga chaicho, research-giredhi, uye premium-mhando Ostarine ikozvino kubva pakanakisa MaSARM UKchitoro - iyo SARM Chitoro nemutengo unonzwisisika zvinoshamisa.