YK-11
YK-11, inozivikanwawo seMyostine, inorongwa zvakanyanya kwazvo nehunyanzvi hwekuvaka muviri uye vatambi vemasimba pasirese. Iyi synthetic uye steroidal inosarudza uyerogen receptor modulator (SARM) ine yakafanana anabolic basa iro rakafanana chaizvo nevanabolic androgenic steroids mune zvakasikwa.
YK-11 yakatanga kufundwa mu2011 nemuongorori wechiJapan Yuichiro Kanno. Yakawanikwa iri yega agonist yeiyo androgen receptor ine gene-inosarudza hunhu. Zvidzidzo munguva yakapfuura zvakaratidza izvozvo YK-11 ine zvirinani kuvaka mhasuru mhedzisiro kupfuura Dihydrotestosterone (DHT). Iyo ine simba rekuita seMyostatin inhibitor.
Chii chinonzi Myostatin Inhibitor?
Myostatin (inonziwo kukura kwekusiyanisa chinhu 8) ipuroteni inogadzirwa uye inoburitswa nemyocyte (mhando yesero rinowanikwa mune mhasuru nyama) inoshanda pane iyo autocrine mashandiro emaseru maseru kutadzisa myogenesis: kukura uye kusiyanisa kwemhasuru maseru.
Chaizvoizvo, Myostatin inochengetedza muviri kubva mukukura zvakanyanya mhasuru. Iyo Myostatin inhibitor senge YK-11 inhibits kuti yakawanda sei Myostatin iri mumuviri uye izvi zvinokutendera iwe kupfuura yako mhasuru yekuvaka uye yekuvaka muviri zvikumbaridzo. Pamusoro peizvi, YK-11 zvakare ine mukana wekuwedzera Follistatin, proteinin-inosunga protein, kusvika padanho rakakura. Mune mamwe mazwi, YK-11 inobatsira muviri kuburitsa zvakakosha zvakanyanya maererano nehuremu hwemhasuru iyo ingadai yakave isingasvikike.
YK-11 Inoshanda Sei?
YK-11 inozvinamatira kune iyo androgen receptor iyo inokonzeresa maseru maseru kuti agadzire agadzire akawanda eanabolic zvinhu. Kusiyana nemaSARM mazhinji, YK-11 haiuye neakaganhurirwa mhedzisiro uye inotungamira mukukura kwemhasuru. Pamusoro pezvakanaka izvi, YK-11 inokurudzirawo kuchengetwa kwemhasuru, kukura kwemhasuru, uye kukura kwemaseru matsva.
Iyi geni-inosarudzira chikamu agonist yeanogamuchira uyerogen inonyatso kuzivikanwa nekugona kwayo kwakasarudzika kwekusimudzira chero hukama hwepanyama pakati peNTD / AF1 neLBD / AF2 [N-terminal domain (NTD) uye activation function (AF); AF1 uye AF2 zviri mukati meiyo NTD uye iyo ligand-inosunga domain (LBD) uye inodzora chiitiko che transcriptional cheiyo estrogen receptor (ER)] iyo inodikanwa kune iyo yakazara transactivation yeiyo androgen receptor. YK-11 inoratidza anabolic chiitiko mu vitro muC2C12 myoblasts uye inopa zvirinani potency mukuenzanisa ne dihydrotestosterone (DHT) mune ino mamiriro.
Naizvozvo, zvinoratidza kuva imwe nzira yakanaka kune wese munhu ari kutsvaga kutsiva vanabolic steroid iyo inowanzo kuve yekunyepedzera, yepasi-yakajairwa, uye inotungamira kune zvakakomba mhedzisiro. YK-11 zvakare isarudzo inoshamisa kune vanhu vane hutano-vanoziva avo vanoda kuchengetedza mhando uye huwandu hwemhasuru uku uchichengeta kure nemafuta maseru.
YK-11 Uye Testosterone-Kuenzanisa
Testosterone ihormone inonetsa inowanikwa mumuviri wemunhu. Inoshanda zvese seanabolic steroid uye bonde hormone.
YK-11 uye Testosterone zvakafanana mukushanda uye nemasikirwo. Musiyano wega wega ndewekuti YK-11 inogadzirirwa kutarisa chete pane mamwe maseru apo Testosterone inoshanda pane akawanda maseru mumuviri wemunhu. Izvo zvakakosha kuti uone pano izvo chero chinhu chinopfuura maseru echisimba muropa chinogona kukonzera zvisingafadzi mhedzisiro senge kuwedzera kweprostate. Mune mamwe mazwi, kushandiswa kweyakagadzirwa testosterone kana majekiseni e testosterone kwenguva yakareba haina kumbobvira yakurudzirwa sezvo mabhenefiti akakundwa neasina kunaka, kunyanya kana testosterone ichiiswa muhuwandu hwakawanda.
YK-11 inopindura kune chaiwo matishu chete uye nekudaro ayo mhedzisiro mhedzisiro zero kana anenge mashoma. Zvakare, YK-11 inogona kupihwa mune yemumuromo fomu iyo zvese zviri zviviri zvakachengeteka uye zviri nyore kana ichienzaniswa neiyo testosterone majekiseni ayo anogona kutungamira mukubuda kwekuputika, kugovana nesingano, uye kurwadziwa kunzvimbo dzejekiseni.
Zvakanakira YK-11
Imwe yemabhenefiti akakurisa eYK-11 ndeyekuti inobatsira mukukura mhasuru nyowani pamusoro peiyo yatosvika padanho rekushomeka kwemajini. Izvi, zvakare, zvinomutsa kuwedzera kweiyo nhanho yemhasuru corset uye kuomarara.
Izvi zvinorevawo kuti tsandanyama dzinorema dzemuviri dzinobva dzatadza kuneta kana kushomeka kunyangwe panguva dzekudzidziswa kwecardio uye nekushanda kwakanyanya. Nekuda kweizvozvo, kurovedza muviri uye kudzidzisa zvikamu zvichave zvakareba uye zvakanyanya kushanda uye zvine simba. Izvi zvakare zvichave nechokwadi chekuti mhedzisiro yakawanikwa inogona kuchengetedzwa nyore nyore kwenguva yakareba mushure meYK-11 kutenderera kwapera.
Iko kushandiswa kweYK-11 kunoenderanawo nezvakanaka zvikuru, zvinosanganisira asi zvisingagumiri ku:
- Kwete anabolic steroid nemigumisiro
- Inogonesa kuomesa tsandanyama
- Inhibition yeMyostatin mazinga
- Kuwedzera mu Follistatin mazinga
- Mapampu ari nani uye kuwedzerwa kwetsandanyama kuzara
- Wedzera musimba simba uye saizi
- Akazendamira mhasuru yemahara kuwana pasina kuyerera kwekuchengetedza
- Inoderedza kukwegura kwemajeri
- Kuvandudza kweropa
- Kunowedzera kutsungirira
- Inokurudzira kupisa mafuta
- Inobatsira iwe kubvisa akaomeswa epamuviri uye visceral mafuta
- Inodzivirira kurasikirwa kwemhasuru panguva yekurasikirwa uremu
- Inodzivirira kukuvara kweiyo neuronal
- Inokurudzira yakasimba mhasuru kukura pasina chiitiko chekudzosera kumashure
- YK-11 inogona kuwedzerwa kune ese marudzi ecycle ekuwedzera simba uye mhasuru kukura
YK-11 Kubvisa Kurudziro
Iyo yakakurudzirwa dhizaini yeYK-11 ndeye 2-5mg (yevakadzi) kaviri uye 5-10mg kaviri pazuva (yevarume), kunyanya nekudya, kwenguva yemavhiki 6-8. Vamwe vanhurume vanoshandisa vanoto wedzera madosi eYK-11 kusvika 20mg pazuva pamusoro peiyo steroid kutenderera kana maSARM kutenderera neYK-11 kunyangwe zvichingogara zviri nani kutanga kushandisa YK-11 pamutero wakaderera mumatanho ekutanga uye tsvaga nzvimbo yako inotapira. Kutenderera neYK-11 kunofanira kugara kuchipera ne post post kutenderera kurapwa kuti ugare wakadzivirirwa uye chengetedza zviwanikwa zvakaitwa neiyi inoshamisa SARM
Hafu-Hupenyu YeYK-11-Matipi Uye Matanho
YK-11, senge maSARM mazhinji, haasi hepatotoxic sezvo asiri emethylated. Uyezve, inoratidzirwa nehupamhi hwehukama hwekuwanikwa bioavailability zvinoreva kuti YK-11 inogona kuiswa nyore nyore pachinzvimbo chekujowa. Hafu yeupenyu yeYK-11 ingangoita maawa mashanu kusvika masere.
Izvo zvakakosha kuti uzive kuti YK-11 haina kukurudzirwa kune vakadzi vane nhumbu uye vanoyamwisa. YK-11 haina zvakare kurayirwa kune vanhu vari allergic kune ayo anoshanda uye asiri-anoshanda zvigadzirwa. Zvakare, kushandiswa kweYK-11 kunofanirwa kugara uye kuchingo gadzirirwa zvinangwa zviri pamutemo pasi pekutarisirwa kwakasimba kwechiremba. Iyo mibairo yeYK-11 haifanire kumbowedzerwa pasina kutanga kurudziro yekurapa.
YK-11 Mamiriro Ekuchengetedza
YK-11 inonyanya kuchengetwa munzvimbo ine rima uye inotonhorera, iri kure nezuva, kupisa, uye hunyoro. Inonyatso chengetwa pakamuri inodzorwa tembiricha ye0 - 4 madigiri Celsius kwenguva pfupi (mazuva kusvika mavhiki) kana -20 madigiri Celsius kwenguva yakareba (mwedzi kusvika kumakore), kunze kwekunge zvataurwa neimwe nzira.
YK-11 Kuisira
Zvekuita zvakanyanya, vazhinji vanogadzira muviri uye magetsi ekuisa masimba vanogadzira YK-11 neIbutamoren (MK-677). Iko kusanganiswa kweMK-677 uye YK-11 kunogadzira nharaunda yakanaka yesimba rakakura, mhasuru, saizi yemhasuru, uye mhasuru yekukura inowana. YK-11 zvakare yakasunganidzwa ne Testolone (RAD-140) yekuona kujekesa shanduko mumuviri.
YK-11 yakaiswawo pamwe neLigandrol (LGD-4033) inozivikanwa nekukonzeresa yakakosha yakaonda mhasuru mhanya. Kana iwe uri kuronga kumhanya RAD-140 uye YK-11 mukutenderera kwevhiki 6-8, RAD-140 inoshandiswa zvakanyanya mumadosi ezuva nezuva e15-30mg pamwe ne10mg yeYK-11 mazuva ese. Kune rimwe divi, yakanaka LGD-4033 uye YK-11 stack inonyatsoitwa ne10-15mg ye LGD mazuva ese pamwe ne5-10mg yeYK-11 mazuva ese.
YK-11 Mhedzisiro
Mhedzisiro neYK-11 inoshamisa chose, kutaura zvishoma. Izvi zvinongoitika nekuti ine vanabolic mhedzisiro pane ese mapfupa uye mhasuru tishu. Hazvishamisi kuti YK-11 inoonekwa nevemaindasitiri nyanzvi nevashandisi seSARM yakasimba kwazvo inowanikwa.
Iko kushandiswa kweYK-11, kana kuchizadzikiswa nechikafu chakanaka uye kushanda kwakanyanya, kunogona kukubatsira nyore kurongedza pa10lbs yemhando yemhasuru mukati menguva ye6-8 mavhiki. Iyi mhasuru inowana munguva pfupi yakadaro inotora mazera kuti iwane nenzira yechisikigo. Paindaneti YK-11 ongororo yaizokubatsira iwe kuona iwo chaiwo mabhenefiti eYK-11. Ruzhinji rwevashandisi vanotaura zvisati zvamboitika uye zvakapenga mhasuru uye simba rinowana pavanenge vachitsvaga neYK-11.
Maitiro Ekutenga YK-11 Pamhepo-YK-11 Kutengesa
YK-11 inogona kutengwa zviri nyore paInternet uchishandisa yakachengeteka uye yakachengeteka nzira dzekubhadhara. Nekudaro, iwe unofanirwa kugara uchicherekedza yakakwira pfungwa yekutarisira uye kushingairira iwe uchiita kutenga sezvo paine yakawanda yekunyepedzera YK-11 vagadziri online. Kutenga kuburikidza navo hazvingoreve chete kuti ucharasikirwa nemari yako yawakawana zvakaoma, asi zvakare zvinoreva kuti unenge uchishandisa nyepera kana pasi-dosed kana sub-standard YK-11 izvo zvinogona kutungamira kune zvakakomba mhedzisiro.
Naizvozvo, zvinogara zvichikurudzirwa kutenga YK-11 online chete kubva kune anozivikanwa maSARM mutengesi senge SARM Chitoro iyo inoshanda chete muprimiyamu, yekutsvagisa-giredhi YK-11.