Yohimbine
Yohimbine, alpha-2 adrenergic receptor antagonist, ndeimwe yezvinhu zvinozivikanwa kwazvo mu pre-Workout, mafuta-anopisa, uye zvekudya zvinowedzera. Yohimbine zvinowedzerwa zvinoshandiswa zvakasiyana siyana zvinangwa, kusanganisira asi zvisingagumira pakukurudzira uremu uye kurapa erectile dysfunction (ED). Yohimbine inoshanda zvakaenzana kurapa matambudziko epabonde ari mhedzisiro yemishonga yekushushikana inonzi selective-serotonin reuptake inhibitors (SSRIs). Iyo zvakare inoshandiswa nevatambi uye vavaki vemuviri kuvandudza mashandiro uye Yohimbine inozivikanwa zvakare kudzikisira kutya kwakanangana nemamwe maphobias.
Chiito Mashini YaYohimbine
Yohimbine inhibits alpha-1 uye alpha-2 adrenoceptors, inoderedza maserotonin mazinga, uye inowedzera iwo mazinga e dopamine uye adrenaline. Iyo inozivikanwa zvakare kudzikisa mashuga eropa, kusunungura insulin, uye kuwedzera kuwedzera kweropa. Inotungamira mukuwedzera kwemitezo yeropa renhengo uye kutapurirana kutsva kumitezo yekubereka. Yohimbine inozivikanwa zvakare kuti inowedzera kusagadzikana kusanzwisisika mudunhu re sacral repelinha. Izvo zvese zvinozivikanwa neserotonin receptor blocking yayo, calcium chiteshi ichivharira, uye monoamine oxidase inhibiting mhedzisiro.
Yohimbine inhibits presynaptic alpha-2 adrenergic receptors zvakanyanya pamitsetse ye Reserpine kunyange chiito chayo chiri chenguva pfupi uye isina kusimba. Iyo yepedyo autonomic nervous system mhedzisiro yeYohimbine ndeyekudzora tsitsi (adrenergic) uye kuwedzera parasympathetic (cholinergic) chiitiko. Izvo zvakakosha kuti urangarire pano kuti kukwidziridzwa mune zvechirume zvekuita bonde kwakabatana neicho cholinergic chiitiko uye kune alpha-2 adrenergic blockade iyo inogona dzidziso kutungamira kudzikisira kana kuwedzera penile inflow, kana ese ari maviri.
Kubvisa yakaomarara subcutaneous mafuta zvitoro sekudya kwako pasi kazhinji kunonetsa kuita nekuda kwezvikonzero zvinoverengeka. Hazvishamise kuti vazhinji vedu tinoona vaine dzimwe nzvimbo dzino "simbaradza" kana kuti vasingaregi nyore mafuta akashata [anowanzove akaderera pasi, ezasi kumashure, uye chiuno chevarume nemakumbo uye chiuno chevakadzi]. Kazhinji kazhinji kwete, izvi zvinokonzerwa nekuwanda kwakanyanya kweAlpha-2 Receptors mumasero ane mafuta anotaurira muviri kuti ubatisise mafuta munzvimbo idzi kuitira kurarama. Yohimbine inodzivirira aya maAlpha-2 Anogamuchira uye nekudaro inouraya meseji yekuchengetedza iwo mafuta akaomarara. Iyo zvakare inosunungura iwo mafuta eiyo oxidisation (kupisa).
Enzymatic Kutaurirana
Yohimbine ine mukana wekudyidzana neCYP2D6 enzyme uye inhibit kushanda kwayo. Imwe ongororo yekuyera Ki yakacherekedza inoonekwa Ki ye0.52uM yeakanatswa maCYP2D6 enzymes uye 0.23uM yemicrosomes. Izvi zvinowedzera kuCorynanthine ine yakajeka Ki ye0.08uM. Izvo zvakakosha kuti uzive pano kuti iyi ndiyo imwechete enzyme iyo inogaya Yohimbine mu11-hydroxy Yohimbine uye inoratidza pamusoro pekupfuura kwakapetwa ka1000 pakati pevanhu zvichibva paCYP2D6 yakaratidza genotype (isina kudyidzana neCYP3A4).
Bhenefiti YaYohimbine
- Yohimbine inobatsira kubvisa zvishuwo zvisingadiwe.
- Inobatsira kurwisa kuomesa mafuta emimba.
- Yohimbine inoderedza mafuta mashoma isingakanganise huremu hwakaonda hwakakosha mukugadzirisa kuumbwa kwemuviri.
- Iyo inovandudza kurovedza muviri nekudzima kuneta kwemuviri icho chiri chinhu chakanaka kungoita nekuti kuita kwekurovedza muviri kunogona kuderedzwa nekuda kwekushomeka kwekoriori.
- Yohimbine inowedzera metabolism yeakanakisa mafuta-kupisa zviitiko.
- Iyo inoshamisa inovandudza kutsungirira uye masimba mazinga.
- Yohimbine chechipiri kune chisina kupisa ruoko rwakasindimara, rudo rwekubata, glutes (garo), uye mafuta ezvidya.
- Yohimbine inoshanda yakakura seyakashanda chishuwo chekudzvinyirira.
- Izvo zvinoshamisa zvine simba zvinokurudzira zvivakwa zveYohimbine zvinoita kuti ive sarudzo huru kune vatambi, mukati nekunze kwenhandare.
- Kwete izvi chete, Yohimbine inonyanya kuwedzera zviyero zvekuzviisa pasi zvekugutsikana pabonde, chishuwo, kuwanda kwekusangana pabonde, uye mhando yezvisungo panguva yepabonde.
- Iyo zvakare inoderedza zvese zviri zviviri zvepanyama uye zvepfungwa zviratidzo izvo zvinowanzo kuve zvine hukama ne erectile dysfunction.
Adrenergic Neurotransmission
Iyo inonyanya kutsvakirwa uye yekutanga mashandiro eYohimbine ndiko kusagadzikana (kupesana) kwekirasi reanogamuchira anonzi seAlpha-2-Adrenergic receptors. Yohimbine inhibits izvi autoreceoptors pane presynaptic noradrenergic neurons kuwedzera kuburitswa kwe noradrenaline sezvo isina kunaka mhinduro inhibition loop ichivhiringidzika.
Yohimbine Uye Kutya Kutsakatika
Yohimbine ine yakasarudzika kugona kuomesa kutya kutsakatika icho chiitiko chepfungwa apo kuenderera mberi kwekuratidzira kune kunotyisa kukurudzira kunowanzo kutungamira mukushushikana kune izvo zvinokonzeresa uye kuderedzwa kana kubvisa kutya kwakabatana nako. Icho chiri chikonzero ichi kuti Yohimbine inosanganisirwa nekuvandudzwa kwekutya kutsakatika kwechipiri kune ekurapa kurapwa.
Yohimbine Uye Kurasikirwa Kwemafuta
Yohimbine inoshanda pane adrenergic receptor system yemafuta maseru ayo anodzora thermogenesis. Iwo beta-masuniti eadrenergic receptors, ayo anovavarira ephedrine, anoonekwa sekurasikirwa kwemafuta kunosimudzira sezvavanosimudzira chiitiko cheAdenyl Cyclase (enzyme) uyezve Cyclic adenosine monophosphate [(yakabva kune adenosine triphosphate (ATP)] .
Izvo zvakakosha kuti urangarire pano kuti ma alpha-masununiti anonyanya kudzvanyirira maitiro emafuta metabolism. Yohimbine, kuve inosarudzika alpha-2 adrenergic receptor anopikisa (inactivator), inodzivisa kumisikidza kweanodzvinyirira receptor maseti uye inochengetedza chiitiko cheAdenyl Cyclase uye nemhedzisiro mhedzisiro kuburikidza ne beta receptors.
Ungatora Sei Yohimbine?
Kazhinji, Yohimbine inonyanya kushandiswa mumadosi ezuva nezuva e0.2 mg pa kilogiramu yehuremu hwemuviri kupisa mafuta. Izvi zvaizoreva muyero we14mg ye150lb munhu kana 18 mg ye q 200lb yega. Izvo zvakakosha kuti uzive pano kuti Yohimbine yekuwedzera inoshanda zvakanyanya panguva pfupi-yekutsanya kana pakati pekudya. Kana iwe uine kusahadzika kana nyonganiso maererano neyakanaka yohimbine dosage, zvinogara zviri nani kuve neshoko nachiremba wako wepedyo kana chemishonga pane kutora zvisiri izvo yohimbine dosages.
Sezvineiwo, Yohimbine inonyanya kugadziriswa isati yatsanya cardio. Insulin inopwanya mhedzisiro yeYohimbine pane iyo Alpha-2 Receptors. Naizvozvo, kudya padhuze nekushandisa Yohimbine kunenge kusingabatsiri uye inogara iri pfungwa yakanaka yekutsanya kweanenge maawa 3-4 usati waita yohimbine. Kechipiri, mafuta anodikanwa kuti apiswe mushure mekunge maAlpha-2 Receptors avharwa. Izvi zvinoreva kuti muviri unofanirwa kunge uchiita imwe nzira yechiitiko uye zvirokwazvo hapana chiitiko chiri nani pane kutsanya cardio.
Kuisira Yohimbine
Yohimbine inogona kuturikidzana neKusarudza uyerogen receptor modulators senge Ostarine(MK-2866), Ibutamoren(MK-677), Andarine(S-4), LGD-4033, uye Cardarine(GW-501516).
Iwo matura eGW-501516 uye Yohimbine anosarudzika mune inopfuura nzira chete. Cardarine yakakosha kuti uwane zvakadzama mukugadzirira kwepamberi uye nekuvandudza kutsungirira. Izvo zvakaenzana zvinobudirira kubvisa kunzwa kwekunayiwa panguva yekushanda kwakanyanya nekuda kwehuwandu hwakawanda hwecardio uye yakaderera carbs. Mune mamwe mazwi, Cardarine anokubatsira iwe kuita zvimwe reps nehuremu hunorema munzira dziri nani. Kana izvo zvisiri izvo zvese, inoshandura simba rinodiwa remuviri kubva paglucose (makabhohaidhiretsi) kuenda kumafuta zvinoreva kuti uchapisa mafuta akawanda zuva rese. Izvi zvakare zvinoreva kuti kuchave nekuwanda kweakachengetwa glycogen kuitira ramangwana rakanyanya kurovedzwa. Kune rimwe divi, Yohimbine iri pachena kupfuura GW-501516.
Contraindication / Kuchengetedza
Yohimbine inopesana kune vanhu vane nhoroondo yekurapa kana variko varikunetseka nematambudziko ehutano sekushushikana, kushushikana, hypotension, angina, chirwere cheitsvo, kana chirwere chechiropa. Izvo zvakare hazvikurudzirwe kune vakadzi vane nhumbu kana vanoyamwisa uye kunyangwe vana. Iko kushandiswa kweYohimbine kunofanirwa kugadzirwa nekuchenjerera kana urikurwara neshuga, schizophrenia, hypertension, kana benign prostatic hyperplasia.
Izvo zvakakosha kuti uzive kuti Yohimbine inoratidza yekuwedzera mhedzisiro ne monoamine oxidase inhibitors. Yohimbine inogona kudzikisa kana kuwedzera kuwedzera kweropa ne tricyclic antidepressants.
Madhiri eYohimbine haafanire kuwedzerwa kana kushungurudzwa chero nguva yenguva netariro yekukurumidza mhedzisiro. Kushungurudzwa kweYohimbine kunogona kutungamira kumhedzisiro senge yekurumwa, dzungu, uye kugadzikana kwekuita. Iko kushandiswa kweYohimbine kunofanira kugara kuchiteverwa nekumbobvunzana kubva kune chiremba.
Sei Kutenga Yohimbine?
Kana uri kutarisa buy Yohimbine, tinokurudzira kusarudza chete yakakurumbira mutengesi weYohimbine sengeSARM Chitoro. Izvi zvinongoitika nekuti kune vakawandisa vatengesi venhema veYohimbine kunze uko uye kuvimba navo zvinoreva kuti hausi kungorasikirwa nemari yako yawakawana zvakaoma, asiwo kuisa pachena muviri wako kune zvigadzirwa zvekunyepera, zvepasi-pasi, kana zvidiki-zviyero.
Kune izvi, zvinogara zvichikurudzirwa kuti uverenge ongororo, mhinduro, mazano, uye zvichemo (kana zviripo) kubva kune akasiyana mukurumbira ekuvaka muviri uye ekuwedzera maforamu. Izvi zvinokubatsira iwe kuziva vatengesi veYohimbine uye sarudza yakanakisa Yohimbine zvinowirirana kuti zvienderane neako chaiwo kuvaka muviri, hutano, uye kugwinya, zvinodiwa., Zvakare, zvinokubatsira iwe kuita sarudzo ine ruzivo yekugara yakachengetedzwa kubva kune zvingangoitika zveYohimbine kushungurudzwa. Rangarira, zvinogara zviri nani kugara wakachengetedzwa uye kushandisa Yohimbine kune zvako zvekuwedzera zvinodiwa hazvisi izvo.