Izvo Izvo Uye Nei zveYohimbine
Mumakore mashoma apfuura, Yohimbine anga ari iwo musoro wekupokana kukuru pakati peindasitiri mukati uye vanofarira kugwinya zvakafanana.
Kana iwe uchitsvaga iko kuita kwekusimudzira mushonga unogona kukubatsira iwe kuti uwane mhasuru uye kurasikirwa nemafuta iwe uchivandudza mashandiro ako muimba yekurara, inguva yekuti iwe uverenge zvakawanda nezve chinoshamisa mushonga unozivikanwa Yohimbine.
Yohimbine, indole alkaloid yakatorwa kubva mumakwati eCentral African Yohimbe muti, inozivikanwa nekupa akasiyana mabhenefiti. Iine basa seye dopamine receptor D2 anopikisa, serotonergic antagonist, uye alpha-adrenergic anopikisa.
Pharmacology
Yohimbine inogona kunyatsotsanangurwa seye indolalkylamine alkaloid nemakemikari akafanana ku reserpine. Iyo ine mukana wekudzivirira presynaptic alpha-2 adrenergic receptors. Iyo yepedyo autonomic nervous system mhedzisiro yeYohimbine ndeyekuderedza kunzwira tsitsi (adrenergic) uye kuwedzera parasympathetic (cholinergic) chiitiko.
Yohimbine inozivikanwa zvakare kuti inhibit alpha-1 uye alpha-2 adrenoceptors. Nokuita izvi, zvinokurudzira kuwedzera kweadrenaline uye dopamine uye kunoderedza maserotonin mazinga. Izvi, zvakare, zvinobatsira mukuburitsa insulin uye kudzikira kweshuga yeropa. Mushonga uyu inozivikanwa zvakare kuti inhibit dopamine-2 uye dopamine-3 (D2 uye D3) receptors uye serotonin-1B, -1D, -2A, uye -2B (5-HT1B, 5-HT1D, 5-HT2A, uye 5- HT2B) zvinogamuchirwa.
Izvo zvakakosha kuti uone pano kuti kukwidziridzwa mune zvechirume zvekuita bonde zvine chekuita neye cholinergic chiitiko uye kune alpha-2 adrenergic blockade iyo inofungidzira kuti inotungamira kune yakawedzera kana kuderera (kana ese ari maviri) penile inflow. Yohimbine ine mhedzisiro yayo yakanaka pakukwanisa kwe erectile nekugadzira kuwedzera kwakakura kwekunzwira tsitsi dhiraivha yechipiri kusvika pakuburitswa mu norepinephrine. Iyo zvakare ine kugona kwe kukurudzira chiyero chemasero mu noradrenergic nuclei yeuropi.
Yohimbine Uye Kurasikirwa Kwemafuta
Yohimbine inonyanya kufarirwa nevatambi uye vavaki vemuviri panguva yeSARM yekucheka macircule nekuda kwesimba rayo sehuremu hwekudzora mushonga.
Alpha-2 zvinogamuchirwa zvakajairika munzvimbo dzemuviri dzinowanzo kuunganidza mafuta zvakasarudzika: zvidya, mazamu, dumbu, uye magaro. Alpha-2 masayiti ekugamuchira kana akafumurwa kutenderera catecholamines senge epinephrine uye norepinephrine inodzivisa kuburitswa kwemafuta acids (lipolysis) nepo beta receptors ichikurudzira lipolysis.
Chaizvoizvo, kuburitswa kwemafuta acids kubva kune adipose tishu muropa inokurudzirwa neglucagon, adrenocorticotropic hormone (ACTH), epinephrine, norepinephrine, uye hormone yekukura. Mafuta acids kamwe muropa reropa anowanzo kukurumidza kusanganiswa kana kuwanda kwemafuta acid ropa risina kukwidziridzwa kubva kune mafuta acid yekuisa inoitika nekudya.
Kazhinji, fatty acid yeropa yekumanikidza inofarira mafuta ekuchengetedza kana iwo akakwirira ayo anokonzerwa nekusaita uye nekudya zvakanyanya. Hypothetically kutaura, kuvharirwa kwe alpha-2 receptors kunoratidza kunobatsira kusunungura ma catecholamines senge norepinephrine panguva yekuremerwa uremu izvo zvinoita kuti zviwanikwe zvakanyanya kukurudzira nzvimbo dze beta receptor dzinoguma nehuremu hwakanyanya hwe lipolysis. Yohimbine kuburikidza neayo alpha 2-adrenergic receptor antagonist chiitiko chinowedzera norepinephrine mazinga muropa.
Zvokurapa Zvinoshandisa zveYohimbine
Yohimbine inoshanda zvakanyanya kana zvasvika pakurapa kushaya simba. Ichi ndicho chimwe chezvikonzero zvikuru nei Yohimbine achigara achiratidzirwa senzwira uye mydriatic kuvarume vechirume vane vascular kana psychogenic uye chirwere cheshuga. Yohimbine inoratidzwa zvakare pakurapa zvinowanzoitika pabonde mune varume nevakadzi.
Kushandiswa kwe Yohimbine zvinowedzera inosanganisirwa nekuvandudzika kunoshamisa mumatanho ekudzikira uremu, kuita kwemitambo, kumanikidza kweropa, uye kuyerera kweropa mumuviri. Iyo zvakare inoshandiswa kurapa akasiyana siyana ehutano matambudziko anosanganisira asi asingagumiri kuhope, kufutisa, syncope, kuora mwoyo, chirwere cheshuga, uye kushaya kwemurume.
Yohimbine inobatsirawo kurapa yakaoma muromo chirwere kana xerostomia, hutano mamiriro umo mune kuderera kweuwandu hwemate inogadzirwa. Izvo zvakakosha kuti uzive pano kuti kugadzirwa kwemate kunowedzerwa neAcetylcholine uye inodzorwa nealpha-2-adrenoceptors. Vanhu vanoonekwa kuti vane xerostomia vanotambura nekushayikwa kweacetylcholine uye Yohimbine anovabatsira nekuwedzera acetylcholine.
Iyo inowanzo-kufuratirwa mukana weYohimbine kugona kwayo kwakasarudzika kurapa vanhu vane ovhadhozi yaClonidine, unova mushonga wekurapa unoshandiswa pakurapa Cherechedza-kukanganisa / kusagadzikana kwehutano(ADHD), Yakakwira BP, yakakwira BP, kusagadzikana kwekushushikana, uye kubvisa zviratidzo.
Yohimbine mukubatana neNaloxone (mushonga unorapa opioid overdose) zvakare inoratidza kugona kurapa Polycystic ovary chirwere izvo zvakasiyana zviratidzo zvinoitika mumadzimai ane akanyanya mwero mahormone echirume (androgens)
Yohimbine Bhenefiti YeVamhanyi Uye Vavaki vemuviri
Yohimbine inozivikanwa zvakare kudzikisira kutya iyo inosangana nemamwe maphobia. Nekuita izvi, zvinobatsira vatambi uye vamwe vezvemitambo kukwira kumusoro uye nekukurumidza uye nekuona avo zvimwe-zvisina kuongororwa kana zvekare-zvisingawanikwe zvinangwa.
Imwe yemabhenefiti akakura eYohimbine kana zvasvika pakurasikirwa kwemafuta ndiko kugona kwayo kudya uye kudya. Izvo zvinobatsirawo kuwedzera kuputsika kwemafuta panguva yekutsanya kana usati waekisesaiza. Zvinoenderana ne kudzidza, zuva rega rega Yohimbine yekuwedzera ine kugona kudzikisa mafuta emuviri mumatambi kubva ku9.3 kusvika ku7.1 muzana.
Inonyanyo kuzivikanwa nekugadzira hyperadrenergic physiological mhedzisiro, Yohimbine inonyanya kushandiswa kucheka macircule uko iyo yekutanga chinangwa cheavo mumitambo uye kuvaka muviri kuwana kana kugadzirisa tsandanyama tsananguro. Yohimbine mushonga wakanakisa kuti uwane iyo toni uye kubvaruka kutarisa pamberi pemakwikwi.
Zvakawanda zvemhuka uye zvidzidzo zvevanhu zvakaratidza kuti Yohimbine inoshanda zvakanyanya kubvisa kutya kwezvimwe zvinhu, vanhu, kana mhuka nekuwedzera norepinephrine mazinga. Ichi ndicho chikonzero chikonzero nei ichi chinodhaka chichigara chanyorerwa varwere vane kusagadzikana kwekushushikana munharaunda uye chinovabatsira nekuderedza kusagadzikana munharaunda nekuvandudza mafungiro.
Kwete izvi chete, Yohimbine inobatsirawo kunatsiridza ndangariro yenguva refu nekuvandudza iwo mazinga e norepinephrine. Ichi chinodhaka chinoratidzirawo kushanda nesimba kudzora kugwamba kweropa nekudzivirira alpha-2 adrenoceptors uye kufambisa shanduko yeepinephrine kuita norepinephrine. Hunhu uhwu hunoita kuti Yohimbine ive yakanakisa mushonga wevamitambo vanobatanidzwa mumitambo yakaoma senge chess uye mamwe marongero emitambo. Zvakare, Yohimbine zvakare inovandudza mhando yehupenyu, kuzviremekedza, uye kuzvivimba nekusimudzira pfungwa yekugara zvakanaka.
Tenga Yohimbine izvozvi! Wana maSARM akanakisa kubva kumusoro-akapihwa MaSARM UK chitoro - Iyo SARM Chitoro.
Yakakurudzirwa Dosage YeYohimbine
Iyo yakakurudzirwa muyero weYohimbine yevarume ndeye 25-50mg zuva rega rega, rakakamurwa kuita maviri akaenzana masosi-madhizaini. Mushonga uyu unofanirwa kutorwa pamwe nekudya uye ndoda maminetsi makumi matatu nemakumi matatu nemashanu pasati pamboitwa musangano, mukutenderera kwemavhiki masere kusvika gumi nemaviri. Kune vakadzi, iyo yakayerwa muyero weYohimbine ndeye 30-45mg mazuva ese, yakakamurwa kuita maviri akaenzana masosi-madhizaini. Vakadzi vanofanirwa kutora mushonga uyu pamwe nezvikafu uye zvirinani maminetsi makumi matatu nemakumi matatu nemashanu pasati pamboitwa musangano, mukutenderera kwevhiki sere kusvika gumi nemaviri.
Yohimbine inobatsirawo kurapa anorgasmia (inozivikanwawo seinasmic dysfunction). Chidzidzo chakaratidza kuti madhiri ezuva nezuva e20mg, aine 5 mg kukwira kusvika pakakwirira makumi mashanu emamiririri ezuva nezuva akakosha kune manejimendi anorgasmia.
Yohimbine Kutenderera KweVarume
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Vhiki |
Yohimbine |
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1 |
25mg mazuva ese |
20mg mazuva ese |
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2 |
25mg mazuva ese |
20mg mazuva ese |
|
|
|
3 |
25mg mazuva ese |
20mg mazuva ese |
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|
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4 |
25mg mazuva ese |
20mg mazuva ese |
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5 |
25mg mazuva ese |
20mg mazuva ese |
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|
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6 |
50mg mazuva ese |
20mg mazuva ese |
|
|
|
7 |
50mg mazuva ese |
20mg mazuva ese |
|
|
|
8 |
50mg mazuva ese |
20mg mazuva ese |
|
3 capsules pazuva |
|
9 |
50mg mazuva ese |
20mg mazuva ese |
|
3 capsules pazuva |
|
10 |
50mg mazuva ese |
20mg mazuva ese |
|
3 capsules pazuva |
|
11 |
50mg mazuva ese |
20mg mazuva ese |
|
3 capsules pazuva |
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12 |
50mg mazuva ese |
20mg mazuva ese |
|
3 capsules pazuva |
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13 |
|
|
3 capsules pazuva |
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14 |
|
|
3 capsules pazuva |
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15 |
|
|
3 capsules pazuva |
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16 |
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|
3 capsules pazuva |
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Matipi Uye Matanho
Yohimbine haina kukurudzirwa kune vana nevakadzi vane nhumbu kana kuyamwisa. Inofanira kushandiswa nekuchenjerera kukuru painotorwa pamwe chete nemishonga yehosha yepamusoro yeropa, phenothiazines, kana tricyclic antidepressants. Ichi chikamu hachikurudzirwe kune vanhu vane mamiriro epfungwa uye matambudziko eitsvo.
Kupfuurirazve, kunzwa kwakanyanya kwekutarisira uye kushingairira kunofanirwa kucherechedzwa apo mushonga uyu unopihwa kune vanhu vane nhoroondo yezvekurapa yekuwedzera kunzwira tsitsi kana avo varipo vari kurapwa panguva imwe chete ne tricyclic antidepressants kana zvimwe zvinodhaka izvo zvinogona kukanganisa metabolism ye norepinephrine kana kutora neuronal.
Yohimbine haifanire kumboshungurudzwa sezvo chiri chinhu chine simba. Kushungurudzwa kweYohimbine kunogona kutungamira kumhedzisiro senge kushungurudza, kushushikana, dzungu, uye kutemwa nemusoro. Iko kushandiswa kweYohimbine hakufanirwe kuitwa pamwe nemahemophiliacs uye zvakare hakufanirwe kushandiswa neavo vachangobva kuvhiyiwa sezvo kuchideredza kugwamba. Ropa rakapfava senge warfarin, aspirin, uye heparin haifanire kutorwa padivi naJohimbine.